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The Human Technopole Foundation is looking for an Associate Head of the Cryo-electron Microscopy Facility for the Structural Biology Research Centre, to support electron tomography, correlative light and electron microscopy (CLEM), DualBeam cryo-FIB and single-particle EM workflows.

The Associate Head will work in close collaboration with the Head of the Cryo-EM Facility and will be responsible for maintaining a facility capable of state-of-the-art electron tomography and CLEM, supporting internal and external users and mentoring junior facility staff.

She/He will work with other HT Core Facilities and IT Services to create an optimal research support system.

She/He can participate in and manage research projects whose purpose is to advance the facility.

The Cryo-EM Facility at Human Technopole benefits from state-of-the-art equipment, providing an outstanding platform for both single-particle EM and electron tomography workflows.

The Facility will be equipped, by December 2020/January 2021, with two 300kV TEMs (TFS Titan Krios G4 + Falcon 4 + Gatan K3 + Gatan BioQuantum EF + VPP, and a 300 kV microscope dedicated to room temperature electron tomography), 200kV TEM (TFS Glacios + Falcon 4 + VPP), 120kV TEM (TFS Talos L120C), a DualBeam cryo-FIB system (TFS Aquilos), and at least one fluorescence microscope with a cryo-stage for CLEM applications.

Ancillary equipment includes plunge freezing devices, glow discharger units, plasma cleaner, carbon coating system, and other sample preparation tools for high-pressure freezing, freeze substitution and ultramicrotomy of resin embedded and vitrified samples.

Computing resources for EM-related analysis will also be available.

Key tasks and responsibilities

The Associate Head of the Cryo-EM facility will:

• be responsible for resource planning and maintenance of the Cryo-EM Facility;
• introduce and supervise facility users to EM sample preparation, technical equipment operation (i.e. from specimen handling to data collection) and provide evaluation support;
• interact with the manufacturers and field service engineers of the microscopes and EM ancillary equipment;
• actively participate in facility reviews by external experts;
• actively participate in the overall development of HT core facilities;
• help in designing IT services to meet EM requirements;
• build effective links and collaborations within HT;
• develop and promote networks with other national and international EM facilities;
• support raising third-party funding where possible.

Requirements

• +5 years of hands-on experience in the use of electron tomography DualBeam cryo-FIB system, CLEM (experience with all these techniques or a combination of two of them is an advantage), or SPA;
• Previous experience in technical support role in an EM Core Facility open to internal and external users;
• Fluency in English – HT is an international research institute;
• Proven communication, team building and problem solving skills.

Additional Information

The Cryo-EM Application Specialist will be based in Milan, recently named the city with the best quality of life in Italy (link: https://lab24.ilsole24ore.com/qualita-della-vita/).

HT offers a highly collaborative, international and diverse work environment. The working language is English. HT will foster top quality, interdisciplinary research by promoting a vibrant environment consisting of independent research groups attracting outstanding graduate students and postdoctoral fellows with access to cutting-edge Core Facilities.

HT is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to a leading, internationally competitive research organization. Researchers coming to Italy for the first time, or returning after residing abroad, benefit from very attractive income tax benefits. HT seeks to promote a collegial and family-friendly atmosphere. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical and other social benefits, as well as financial support for relocation and installation, including the family.

Only for general enquires concerning the role, please contact Paolo Swuec (paolo.swuec@fht.org), Head of the Cryo-EM Facility (the email addresses should not be used to send applications).

Please apply sending a CV and motivation letter in English only through the dedicated area below (Apply Now).

Apply Now

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